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ACTH ( Adrenocorticotropic Hormone )
Rate: Rs. 1,250
Sample
1.Patient’s plasma is needed.Place blood immediatly in ice water.and freez plasma in 15 min.Sample should be collected in plastic test tube or heparinised tube.
2.For the diagnosis of Cushing syndrome the sample should be taken between 6 to 11 pm.
Physiology
Corticotropin-releasing-harmone (CRH) released from the hypothalamus and give rise to release of ACTH from the pituitary glands.ACTH is released in reponse to many stresses.
Significance
1.ACTH is unstable in the blood.Most commercial RIA kits are insensitive and nonspecific to measure ACTH.
1.ACTH is advised for investigating disorders of the hypothalamic—pituitary —adrenal system.
1.ACTH is secreted by the anterior pituitary gland that signals the adrenal gland to produce steroids ( androgens, cortisol, and aldosterone).These are needed for the normal functiong of the body.
1.ACTH level is highest in the early morning (6 to 8 am )and in the evening between 6 to 11 pm.
1.ACTH is released in burst so its level can vary from minute to minute.
NORMAL
6 — 8 a.m less than 80 pg / ml
6 — 11 p.m less than 50 pg /ml
or less than 120 pg / ml
Indication
1.This hormone is estimated in various conditions like Adrenal insuffiency, in Cushing syndrome, Acromegaly etc.
2.In Addison’s disease is >1000 pg /ml
3.Its level decreases in secondary Adrenocortical insuffiency, Adrenal carcinoma and adenoma.
4.Pregnany ,menstrual cycle and stress increase the secretion.
